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Clinical and Diagnostic Laboratory Immunology, July 2004, p. 801-805, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.801-805.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Clinical Evaluation of a Chemiluminescence Immunoassay for Determination of Immunoglobulin G Avidity to Human Cytomegalovirus

Maria Grazia Revello, Giovanna Gorini, and Giuseppe Gerna*

Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy

Received 27 September 2003/ Returned for modification 12 February 2004/ Accepted 17 March 2004

Clinical evaluation of a novel fully automated chemiluminescence immunoassay for determination of immunoglobulin G avidity to human cytomegalovirus (HCMV) showed 92.8% sensitivity and 84.7% specificity in detecting a recent (≤90 days) primary HCMV infection. The assay appears useful for accurately diagnosing recent primary HCMV infections.

* Corresponding author. Mailing address: Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy. Phone: 390382502644. Fax: 390382502599. E-mail: g.gerna{at}smatteo.pv.it.

Clinical and Diagnostic Laboratory Immunology, July 2004, p. 801-805, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.801-805.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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