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Clinical and Diagnostic Laboratory Immunology, May 2004, p. 625-626, Vol. 11, No. 3
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.3.625-626.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Toll-Like Receptor 2 Arg677Trp Polymorphism Is Associated with Susceptibility to Tuberculosis in Tunisian Patients

Meriem Ben-Ali,1 Mohamed-Ridha Barbouche,1* Soufia Bousnina,2 Abdellatif Chabbou,2 and Koussay Dellagi1

Laboratoire d'Immunologie, de Vaccinologie et de Génétique Moléculaire, Institut Pasteur de Tunis, Tunis,1 Service de Pneumo-phtysiologie, Centre Hospitalo-Universitaire Abderrahmen Mami, Ariana, Tunisia2

Received 16 September 2003/ Returned for modification 3 November 2003/ Accepted 9 December 2003

Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls (P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis.

* Corresponding author. Mailing address: Laboratoire d'Immunologie, de Vaccinologie et de Génétique Moléculaire, Institut Pasteur de Tunis, 13, Place Pasteur, 1002 Tunis, Tunisia. Phone: 216.71.789608. Fax: 216.71.791833. E-mail: ridha.barbouche{at}pasteur.rns.tn.

Clinical and Diagnostic Laboratory Immunology, May 2004, p. 625-626, Vol. 11, No. 3
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.3.625-626.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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