This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Krakauer, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Krakauer, T.

 Previous Article  |  Next Article 

Clinical and Diagnostic Laboratory Immunology, May 2004, p. 621-624, Vol. 11, No. 3
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.3.621-624.2004

Caspase Inhibitors Attenuate Superantigen-Induced Inflammatory Cytokines, Chemokines, and T-Cell Proliferation

Teresa Krakauer1*

Department of Immunology and Molecular Biology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-50111

Received 6 November 2003/ Returned for modification 19 December 2003/ Accepted 22 January 2004

Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). A pan-caspase inhibitor suppressed SE-stimulated T-cell proliferation and the production of cytokines and chemokines by human peripheral blood mononuclear cells. These data suggest that caspase inhibitors may represent a novel therapeutic modality for treating SE-induced toxic shock.

* Mailing address: Dept. of Immunology and Molecular Biology, 1425 Porter St., USAMRIID, Fort Detrick, Frederick, MD 21702-5011. Phone: (301) 619-4733. Fax: (301) 619-2348. E-mail: teresa.krakauer{at}det.amedd.army.mil.

Clinical and Diagnostic Laboratory Immunology, May 2004, p. 621-624, Vol. 11, No. 3
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.3.621-624.2004




This article has been cited by other articles:

  • Krakauer, T., Little, S. F., Stiles, B. G. (2005). Bacillus anthracis Edema Toxin Inhibits Staphylococcus aureus Enterotoxin B Effects In Vitro: a Potential Protein Therapeutic?. Infect. Immun. 73: 7069-7073 [Abstract] [Full Text]  
  • Bilbo, S. D., Biedenkapp, J. C., Der-Avakian, A., Watkins, L. R., Rudy, J. W., Maier, S. F. (2005). Neonatal Infection-Induced Memory Impairment after Lipopolysaccharide in Adulthood Is Prevented via Caspase-1 Inhibition. J. Neurosci. 25: 8000-8009 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»