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Clinical and Diagnostic Laboratory Immunology, March 2004, p. 337-343, Vol. 11, No. 2
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.2.337-343.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Effects of Infection with Transmissible Gastroenteritis Virus on Concomitant Immune Responses to Dietary and Injected Antigens

Michael Bailey,1 Karin Haverson,1* Bevis Miller,1 Philip Jones,1 Isabel Sola,2 Luis Enjuanes,2 and Christopher R. Stokes1

Department of Clinical Veterinary Science, University of Bristol, Bristol BS40 5DU, United Kingdom,1 Department of Molecular and Cell Biology, National Center of Biotechnology (CNB), CSIC, Campus Universidad Autonoma, 28049 Madrid, Spain2

Received 11 August 2003/ Returned for modification 25 November 2003/ Accepted 22 December 2003

Normal piglets weaned onto soy- or egg-based diets generated antibody responses to fed protein. Concurrent infection with transmissible gastroenteritis virus (TGEV) did not affect the responses to dietary antigens at weaning, nor did it affect the subsequent development of tolerance. However, TGEV infection did enhance the primary immunoglobulin M (IgM) and IgG1, but not IgG2, antibody responses to injected soy in comparison to those of uninfected animals. Paradoxically, TGEV-infected animals showed an enhanced primary IgG1 antibody response to injected soy at 4 weeks of age, but they subsequently showed a reduced secondary response after an intraperitoneal challenge at 9 weeks of age in comparison to uninfected animals. The results suggest that an enteric virus, either used as a vaccine vector or present as a subclinical infection, may not have significant effects on the development of dietary allergies but may have effects both on the primary response and on the subsequent recall response to systemic antigens to which the animal is exposed concurrently with virus antigens.

* Corresponding author. Mailing address: Department of Clinical Veterinary Science, University of Bristol, Bristol BS40 5DU, United Kingdom. Phone: 44 117 9289289. Fax: 44 117 9289505. E-mail: Karin.Haverson{at}bristol.ac.uk.

Clinical and Diagnostic Laboratory Immunology, March 2004, p. 337-343, Vol. 11, No. 2
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.2.337-343.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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