This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Horcajada, J. P. Articles by Mensa, J. Search for Related Content PubMed PubMed Citation Articles by Horcajada, J. P. Articles by Mensa, J.

 Previous Article  |  Next Article 

Clinical and Diagnostic Laboratory Immunology, January 2004, p. 142-146, Vol. 11, No. 1
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.1.142-146.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Evaluation of Inflammatory and Renal-Injury Markers in Women Treated with Antibiotics for Acute Pyelonephritis Caused by Escherichia coli

Juan P. Horcajada,^1* María Velasco,¹ Xavier Filella,² Luisa Alvarez,² Elisa De Làzzari,³ Jose Luis Marín,² Blanca Collvinent,⁴ Alex Smithson,¹ Jose Antonio Martínez,¹ Mariana Noguero,¹ Jordi Vila,⁵ and Josep Mensa¹

Service of Infectious Diseases,¹ Service of Microbiology, Institut Clínic Infeccions i Immunologia,⁵ Service of Clinical Biochemistry, Centre de Diagnostic Biomedic,² Biostatistics and Epidemiology Unit,³ Emergency Room, Hospital Clínic Universitari-IDIBAPS, Barcelona, Spain⁴

Received 13 June 2003/ Returned for modification 21 August 2003/ Accepted 9 October 2003

The evolution and the relationship between inflammatory and renal-injury markers in women with acute uncomplicated pyelonephritis under antimicrobial therapy were investigated in a prospective study. Markers were measured before and 6 and 24 h after the intravenous administration of 1 g of ceftriaxone. Before treatment, the median levels of all markers except the serum creatinine levels were high. Twenty-four hours after the onset of antibiotic treatment, the C-reactive protein (CRP) level continued to be high, while the serum interleukin-6 (IL-6) levels and the urine IL-6, IL-8, albumin, and immunoglobulin G (IgG) levels decreased significantly. In contrast, serum creatinine and tumor necrosis factor alpha levels and urine N-acetyl-ß-glucosaminidase, ₁-microglobulin, and ß₂-microglobulin levels did not change over time. There was a significant correlation between IL-6 and IL-8 levels and urine albumin and IgG levels (urine albumin and IgG levels are glomerular and urinary tract-injury markers) as well as between serum CRP levels and the levels of the tubular-injury markers. In women with acute pyelonephritis, appropriate antibiotic treatment rapidly decreases serum IL-6 levels and urine IL-6 and IL-8 levels, which correlate well with urine albumin and IgG levels.

---

* Corresponding author. Mailing address: Service of Infectious Diseases. Institut Clínic Infeccions i Immunologia, Hospital Clínic Universitari-IDIBAPS, Villaroel 170, 08036 Barcelona, Spain. Phone: 34 932275708. Fax: 34 934514438. E-mail: jhorcaja{at}clinic.ub.es.

---

Clinical and Diagnostic Laboratory Immunology, January 2004, p. 142-146, Vol. 11, No. 1
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.1.142-146.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

This article has been cited by other articles:

• Smithson, A., Sarrias, M. R., Barcelo, J., Suarez, B., Horcajada, J. P., Soto, S. M., Soriano, A., Vila, J., Martinez, J. A., Vives, J., Mensa, J., Lozano, F. (2005). Expression of Interleukin-8 Receptors (CXCR1 and CXCR2) in Premenopausal Women with Recurrent Urinary Tract Infections. CVI 12: 1358-1363 [Abstract] [Full Text]