Files in this Data Supplement:

• Supplemental file 1 - Fig. S1 shows a map of the state of Acre, northwestern Brazil, indicating the sites surveyed in 1999 and the site of the 2004-2005 cohort study.
  Zipped JPEG document, 1.2MB.
• Supplemental file 2 - Fig. S2 shows amino acid sequences of the variants of blocks 2, 6, and 10 and the region of block 13 corresponding to the 3�� portion of its gene.
  MS Word document, 66K.
• Supplemental file 3 - Fig. S3 shows Coomassie blue-stained recombinant proteins representing each PvMSP-1 variant described in Fig. 1B.
  Zipped JPEG document, 43K.
• Supplemental file 4 - Fig. S4 shows data for IgM antibodies to PvMSP-1 variants in sequential samples from malaria-exposed rural Amazonians.
  MS Word document, 32K.
• Supplemental file 5 - Table S1 provides the precise locations and GenBank sequences of PvMSP-1 gene domains.
  MS Word document, 36K.