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Clin. Vaccine Immunol. doi:10.1128/CVI.00430-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Effects of Timing of Processing and Lymphocyte Isolation or Cryopreservation on Detection of CD31 Expression on Naïve CD4 T Cells

AIDS Monitoring Laboratory, Clinical Services Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702; Clinical and Molecular Retroviral Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD 20892

^* To whom correspondence should be addressed. Email: isereti{at}niaid.nih.gov.

	Abstract

Delayed processing of peripheral blood or peripheral blood mononuclear cell isolation and cryopreservation can lead to detection of somewhat higher CD31 expression on naïve CD4 T cells by flow cytometry. These observations should be considered in the planning of multi-center clinical trials and in the interpretation of functional studies.