CVI Accepts, published online ahead of print on 14 October 2009

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Clin. Vaccine Immunol. doi:10.1128/CVI.00302-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Immune Response and Viral Persistence in Indian Buffaloes (Bubalus Bubalis) Infected with Foot-and-Mouth Disease Virus Asia 1

Mohan S Maddur^*, Subodh Kishore, S. Gopalakrishna, Nem Singh, V V Suryanarayana, and Mukund R. Gajendragad

Indian Veterinary Research Institute, Bangalore, 560024, Karnataka, India; Animal Disease Surveillance and Monitoring, Bangalore, 560024, Karnataka, India; Indian Veterinary Research Institute, Izatnagar, 243122, UP, India

^* To whom correspondence should be addressed. Email: mohanms.manu{at}gmail.com.

Despite their potential role in the spread of foot-and-mouth disease (FMD), immune response and viral persistence in FMD virus (FMDV)-infected Indian buffaloes (Bubalus bubalis) have been unexplored. We found similar kinetics of neutralizing antibody response in serum and secretory fluids of buffaloes following experimental FMDV Asia 1 infection. But lymphocyte proliferative response in infected buffaloes was of low magnitude. Despite inducing a significant systemic and secretory immune response, viral persistence seems to be a common outcome in buffaloes following FMDV Asia1 infection that is associated with weak cellular immune response.