CVI Accepts, published online ahead of print on 30 September 2009
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Clin. Vaccine Immunol. doi:10.1128/CVI.00268-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Detection of Invasive Pulmonary Aspergillosis by Lateral Flow Technology Compared to Galactomannan and (1->3)-{beta}-D-Glucan

Nathan P. Wiederhold*, Christopher R. Thornton, Laura K. Najvar, William R. Kirkpatrick, Rosie Bocanegra, and Thomas F. Patterson

University of Texas at Austin College of Pharmacy, Austin, Texas; University of Exeter, Exeter, United Kingdom; University of Texas Health Science Center at San Antonio, San Antonio, Texas; South Texas Veterans Health Care System, San Antonio, Texas

* To whom correspondence should be addressed. Email: wiederholdn{at}uthscsa.edu.


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Abstract

We compared a lateral-flow device to galactomannan and (1->3)-{beta}-D-glucan assays to detect invasive aspergillosis in an established guinea pig model of pulmonary disease. The lateral-flow device became positive earlier (day 3) compared to the (1->3)-{beta}-D-glucan and galactomannan assays (day 5), with all samples positive by each assay on day 7.