CVI Accepts, published online ahead of print on 2 September 2009

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Clin. Vaccine Immunol. doi:10.1128/CVI.00191-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

ANTIBODIES INDUCED BY DENGUE 1 AND DENGUE 2 ENVELOPE DOMAIN III RECOMBINANT PROTEINS IN MONKEYS NEUTRALIZE STRAINS OF DIFFERENT GENOTYPES

Lidice Bernardo, Osmel Fleitas, Alequis Pavón, Lisset Hermida, Gerardo Guillén, and Maria G. Guzman^*

Department of virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, "Pedro Kourí" Tropical Medicine Institute, Autopista Novia del Mediodía, km 6 P.O. Box 601 Marianao 13, Havana, Cuba; Center for Genetic Engineering and Biotechnology, Apdo 6162. Havana 10600, Cuba

^* To whom correspondence should be addressed. Email: lupe{at}ipk.sld.cu.

In the present work we evaluated the neutralizing capacity of the antibodies induced by dengue 1 and dengue 2 envelope domain III recombinant proteins in monkeys against strains of different dengue 1 and dengue 2 genotypes. Here we demonstrated that dengue 1 and dengue 2 recombinant proteins induced high neutralizing antibody titers against different genotype strains.