CVI Accepts, published online ahead of print on 25 July 2007
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Clin. Vaccine Immunol. doi:10.1128/CVI.00137-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Yersinia pestis CO92{Delta}yopH is a potent live-attenuated plague vaccine

Sarah S. Bubeck and Peter H. Dube*

The University of Texas Health Science Center at San Antonio, Department of Microbiology and Immunology, 7703 Floyd Curl Dr., San Antonio, TX 78229

* To whom correspondence should be addressed. Email: dube{at}uthscsa.edu.


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Abstract

An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When used as a live attenuated vaccine CO92{Delta}yopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.




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