CVI Accepts, published online ahead of print on 3 October 2007

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Clin. Vaccine Immunol. doi:10.1128/CVI.00100-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

CD14-159CC, another risk genotype for severe SARS-CoV infection

Fang F Yuan^*, Ingrid Boehm, Paul KS Chan, Katherine Marks, Julian W Tang, David SC Hui, Joseph JY Sung, Wayne B Dyer, Andrew F Geczy, and John S Sullivan

Australian Red Cross Blood Service-Endeavour, Sydney, NSW 2000, Australia; Department of Microbiology, The Chinese University of Hong Kong, Hong Kong; Research Unit of Transfusion Medicine and Immunogenetics, Faculty of Medicine, University of Sydney; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong; Stanley Ho Centre for Emerging Infectious Diseases, School of Public Health, The Chinese University of Hong Kong, Hong Kong

^* To whom correspondence should be addressed. Email: fyuan{at}arcbs.redcross.org.au.

To investigate if other genetic factors of innate immunity might influence susceptibility and/or progression in individuals infected with SARS, we further evaluated CD14 gene polymorphism in 198 Hong Kong blood donors and 152 Hong Kong SARS patients who were previously genotyped for FcRIIA polymorphisms. The prevalence of the CD14-159CC was significantly higher in the severe SARS patients than in the mild SARS group or controls (31% vs. 15% or 20%; P = 0.029; OR: 2.74; 95% CI1.15-6.57 or P = 0.04; OR: 2.41; 95% CI 1.05-5.54, respectively), and both CD14-159CC and FcRIIA-RR131 are risk genotypes for severe SARS-CoV infection.

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