CVI Accepts, published online ahead of print on 14 May 2008
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Clin. Vaccine Immunol. doi:10.1128/CVI.00091-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

A modified caspase-3 assay correlates with immunity of nonhuman primates to infection by Yersinia pestis

Susan Welkos*, Sarah Norris, and Jeffrey Adamovicz

Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, Maryland, 21702, USA; Biostatistical Services Division, USAMRIID, Frederick, Maryland, 21702, USA; and Midwest Research Institute, Frederick, Maryland, 21702, USA

* To whom correspondence should be addressed. Email: susan.welkos{at}amedd.army.mil.


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Abstract

Defined candidate human vaccines for Yersinia pestis, the agent of plague, have been developed. To facilitate evaluations of their efficacy, the in vitro caspase-3 assay for cytotoxicity neutralizing activity was modified and re-evaluated. Immune serum-mediated caspase-3 neutralizing activity correlated with protection in a nonhuman primate vaccine model of plague immunity.




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