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Clin. Vaccine Immunol. doi:10.1128/CVI.00091-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

A modified caspase-3 assay correlates with immunity of nonhuman primates to infection by Yersinia pestis

Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, Maryland, 21702, USA; Biostatistical Services Division, USAMRIID, Frederick, Maryland, 21702, USA; and Midwest Research Institute, Frederick, Maryland, 21702, USA

^* To whom correspondence should be addressed. Email: susan.welkos{at}amedd.army.mil.

	Abstract

Defined candidate human vaccines for Yersinia pestis, the agent of plague, have been developed. To facilitate evaluations of their efficacy, the in vitro caspase-3 assay for cytotoxicity neutralizing activity was modified and re-evaluated. Immune serum-mediated caspase-3 neutralizing activity correlated with protection in a nonhuman primate vaccine model of plague immunity.