CVI Accepts, published online ahead of print on 25 June 2008
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Flores, J.
Right arrow Articles by Okhuysen, P. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Flores, J.
Right arrow Articles by Okhuysen, P. C.

 Previous Article  |  Next Article 

Clin. Vaccine Immunol. doi:10.1128/CVI.00070-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Influence of Host IL-10 Polymorphisms on the Development of Travelers' Diarrhea due to Heat Labile producing Enterotoxigenic Escherichia coli in US Travelers to Mexico

Jose Flores, Herbert L. DuPont, Stephanie A. Lee, Jaime Belkind-Gerson, Mercedes Paredes, Jamal A. Mohamed, Lisa Y. Armitige, Dong-Chuan Guo, and Pablo C. Okhuysen*

The University of Texas at Houston, Medical School, Texas; St. Luke's Episcopal Hospital, Houston, Texas; The University of Texas at Houston, School of Public Health, Texas; Instituto Nacional de Salud Pública, México; Baylor College of Medicine

* To whom correspondence should be addressed. Email: Pablo.c.okhuysen{at}uth.tmc.edu.


arrow
Abstract

Background. Up to 60% of US visitors to Mexico develop travelers' diarrhea (TD), mostly due to Escherichia coli that produce heat labile (ETEC-LT) and/or heat stable (ETEC-ST) enterotoxins. Distinct single nucleotide polymorphisms (SNPs) within the IL-10 promoter have been associated with high, intermediate, or low production of IL-10.

Objective. We conducted a prospective study to investigate the association of SNPs in the IL-10 promoter and the occurrence of travelers' diarrhea in ETEC-LT exposed travelers.

Methods. Sera from US travelers to Mexico collected on arrival and departure was studied for ETEC-LT seroconversion. Pyrosequencing was performed to genotype IL-10 SNPs. Subjects were also studied for other enteropathogens in case of diarrhea.

Results. 121 of 569 (21.3%) travelers seroconverted to ETEC-LT, and among them 75 (62%) developed diarrhea. Symptomatic seroconversion was more commonly seen in subjects who carried a high IL-10 producing genotype; -1082 GG 83% vs. AA 54% (p 0.02), -819 CC 71% vs. TT 33% (p 0.005), -592 CC 71% vs. AA 38% (p 0.02). Travelers with the haplotype GCC were more likely to have symptomatic seroconversion than those with the ATA haplotype (71% vs. 38%, p 0.002).

Conclusions. Travelers genetically predisposed to produce high IL-10 were more likely to experience symptomatic ETEC TD.




This article has been cited by other articles:

  • DuPont, H. L. (2009). Bacterial Diarrhea. NEJM 361: 1560-1569 [Full Text]  
  • Estrada-Garcia, T., Lopez-Saucedo, C., Thompson-Bonilla, R., Abonce, M., Lopez-Hernandez, D., Santos, J. I., Rosado, J. L., DuPont, H. L., Long, K. Z. (2009). Association of Diarrheagenic Escherichia coli Pathotypes with Infection and Diarrhea among Mexican Children and Association of Atypical Enteropathogenic E. coli with Acute Diarrhea. J. Clin. Microbiol. 47: 93-98 [Abstract] [Full Text]