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Clinical and Diagnostic Laboratory Immunology, July 2001, p. 818-821, Vol. 8, No. 4
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.4.818-821.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Viral Load in Breast Milk Correlates with Transmission of Human Cytomegalovirus to Preterm Neonates, but Lactoferrin Concentrations Do Not

B. W. A. van der Strate,1,* M. C. Harmsen,2,3 P. Schäfer,4 P. J. Swart,1,dagger T. H. The,2 G. Jahn,5 C. P. Speer,6 D. K. F. Meijer,1 and K. Hamprecht5

Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, Groningen University Institute for Drug Exploration, 9713 AV Groningen,1 and Department of Clinical Immunology2 and Department of Pathology/Laboratory Medicine,3 Groningen University Institute for Drug Exploration, University Hospital Groningen, 9713 GZ Groningen, The Netherlands, and Institut für Medizinische Mikrobiologie and Immunologie, Universitäts-Krankenhaus Eppendorf, D-20246 Hamburg,4 Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, D-72076 Tübingen,5 and Children's Hospital, University of Würzburg, 97080 Würzburg,6 Germany

Received 27 December 2000/Returned for modification 7 February 2001/Accepted 11 April 2001

In vitro, lactoferrin (LF) strongly inhibits human cytomegalovirus (HCMV), which led us to hypothesize that in vivo HCMV might also be inhibited in secretions with high LF concentrations. In breast milk, high viral loads observed as high viral DNA titers tended to coincide with higher LF levels. However, the LF levels did not correlate to virus transmission to preterm infants. The viral load in the transmitting group was highest compared to the nontransmitting group. We conclude that viral load in breast milk is an important factor for transmission of the virus.

* Corresponding author. Mailing address: Groningen University Institute for Drug Exploration (GUIDE), Department of Pharmacy and Drug Delivery, University Center for Pharmacy, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands. Phone: 31-50-363-7566. Fax: 31-50-363-3247. E-mail: B.W.A.van.der.Strate{at}farm.rug.nl.

dagger Present address: Yamanouchi Europe B.V., 2353 EW Leiderdorp, The Netherlands.

Clinical and Diagnostic Laboratory Immunology, July 2001, p. 818-821, Vol. 8, No. 4
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.4.818-821.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.