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Clinical and Diagnostic Laboratory Immunology, January 1999, p. 133-136, Vol. 6, No. 1
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Streptococcal DNase B Is Immunologically Identical to Superantigen SpeF but Involves Separate Domains

Anna Eriksson,1,* Björn Eriksson,1,2 Stig E. Holm,1 and Mari Norgren1

Department of Clinical Bacteriology, Umeå University, S-901 85 Umeå,1 and Division of Infectious Diseases, Departments of Immunology, Microbiology, Pathobiology, and Infectious Diseases, Karolinska Institute, Huddinge Hospital, S-141 86 Huddinge,2 Sweden

Received 29 April 1998/Returned for modification 4 August 1998/Accepted 8 October 1998

The previous suggestion that streptococcal superantigen SpeF might be identical to DNase B was confirmed in this study. Polyclonal SpeF-specific antisera were able to inhibit depolymerization of methyl-green DNA by DNase B. However, T-cell mitogenicity and nuclease activity appear to involve separate immune epitopes on SpeF, since sera with the capacity to neutralize the mitogenic activity of SpeF did not always inhibit the DNase activity.

* Corresponding author. Mailing address: Department of Clinical Bacteriology, Umeå University, S-901 85 Umeå, Sweden. Phone: 46 90 785-1121. Fax: 46 90 785-2225. E-mail: anna.eriksson{at}climi.umu.se.

Clinical and Diagnostic Laboratory Immunology, January 1999, p. 133-136, Vol. 6, No. 1
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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