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Clinical and Diagnostic Laboratory Immunology, 09 1997, 630-632, Vol 4, No. 5
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Antibodies to the hepatitis B e antigen (HBeAg) can be induced in HBeAg- transgenic mice by adoptive transfer of a specific T-helper 2 cell clone

C Hultgren, DR Milich and M Sallberg
Division of Clinical Virology, Huddinge University Hospital, Sweden.

Production of antibody to hepatitis B e antigen (HBeAg); i.e., anti-HBe antibody,) in HBeAg-transgenic mice is believed to be mediated by T- helper 2 (Th2) cells. Injection of an HBeAg-specific Th2 clone into HBeAg-transgenic H-2k mice induced anti-HBe antibody production, confirming the function of Th2 cells in this model system.




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Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 1997 by the American Society for Microbiology. All rights reserved.