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Clinical and Diagnostic Laboratory Immunology, 07 1997, 491-492, Vol 4, No. 4
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Time to earliest peak serum antibody response to influenza vaccine in the elderly

PA Gross, C Russo, S Dran, P Cataruozolo, G Munk and SC Lancey
Department of Internal Medicine, Hackensack University Medical Center, New Jersey 07601, USA.

The earliest time at which serum antibody levels peak following administration of an influenza virus vaccine in elderly persons is not clearly defined. We compared the time intervals of 1 and 2 weeks after vaccination. A commercial trivalent vaccine containing the hemagglutinins of influenza viruses A/Texas/36/91 (H1N1), A/Johannesburg/33/94 (H3N2), and B/Harbin/7/94 was used. The hemagglutination inhibition (HAI) antibody titers at 1 week after vaccination were significantly lower than the HAI titers at 2 weeks postvaccination for all three vaccine components.

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