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Clinical and Diagnostic Laboratory Immunology, 03 1997, 226-228, Vol 4, No. 2
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Levels of stem cell factor and interleukin-3 in serum in acute Plasmodium falciparum malaria

H Burgmann, S Looareesuwan, EC Wiesinger, W Winter and W Graninger
Department of Internal Medicine I, University of Vienna, Austria.

The purpose of the present study was to measure serum concentrations of stem cell factor (SCF) and interleukin-3 (IL-3) in patients with acute Plasmodium falciparum malaria. Serum samples from 15 patients were taken on day of admission and days 7, 14, 21, and 28. Anemia developed in 80% of patients. A transient increase in IL-3 could be observed at the beginning of the disease. It remains controversial whether the measured concentrations of IL-3 and SCF correlate with the grade of anemia. The possibly suppressed IL-3 and SCF production may contribute to the prolonged anemia in P. falciparum malaria, as has been shown for erythropoietin.

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