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Clinical and Vaccine Immunology, September 2009, p. 1378-1380, Vol. 16, No. 9
1071-412X/09/$08.00+0     doi:10.1128/CVI.00198-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

An Oral Mycobacterium bovis BCG Vaccine for Wildlife Produced in the Absence of Animal-Derived Reagents{triangledown}

Martin L. Cross,* Matthew R. Lambeth, and Frank E. Aldwell

Centre for Innovation, University of Otago, P.O. Box 56, Dunedin, New Zealand

Received 17 May 2009/ Returned for modification 17 June 2009/ Accepted 24 June 2009

Cultures of Mycobacterium bovis BCG, comprising predominantly single-cell bacilli, were prepared in broth without animal-derived reagents. When formulated into a vegetable-derived lipid matrix, the vaccine was stable in vitro and was immunogenic in vivo upon feeding it to mice. This formulation could be useful for oral vaccination of wildlife against tuberculosis, where concern over transmissible prions may preclude the field use of vaccines containing animal products.

* Corresponding author. Mailing address: Centre for Innovation, University of Otago, P.O. Box 56, Dunedin, New Zealand. Phone: 64 3479 5996. Fax: 64 3479 8576. E-mail: frank.cross{at}otago.ac.nz

{triangledown} Published ahead of print on 1 July 2009.

Clinical and Vaccine Immunology, September 2009, p. 1378-1380, Vol. 16, No. 9
1071-412X/09/$08.00+0     doi:10.1128/CVI.00198-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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