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Clinical and Vaccine Immunology, September 2009, p. 1369-1371, Vol. 16, No. 9
1071-412X/09/$08.00+0     doi:10.1128/CVI.00410-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Transcriptional Errors in Human Immunodeficiency Virus Type 1 Generate Targets for T-Cell Responses{triangledown}

Keith E. Garrison,1 Stephane Champiat,1 Vanessa A. York,1 Ashish T. Agrawal,1 Esper G. Kallas,2,3 Jeffrey N. Martin,4 Frederick M. Hecht,5 Steven G. Deeks,5 and Douglas F. Nixon1*

Division of Experimental Medicine, Department of Medicine, UCSF, San Francisco, California 94110,1 Federal University of São Paulo, São Paulo, Brazil,2 Division of Clinical Immunology and Allergy, University of São Paulo, São Paulo, Brazil,3 Department of Epidemiology and Biostatistics, University of California, San Francisco, California,4 HIV/AIDS Division, San Francisco General Hospital, Department of Medicine, University of California, San Francisco, California 941105

Received 14 November 2008/ Returned for modification 30 December 2008/ Accepted 1 June 2009

We measured T-cell responses to human immunodeficiency virus type 1 (HIV-1) cryptic epitopes encoded by regions of the viral genome not normally translated into viral proteins. T-cell responses to cryptic epitopes and to regions normally spliced out of the HIV-1 viral proteins Rev and Tat were detected in HIV-1-infected subjects.

* Corresponding author. Mailing address: University of California—San Francisco, Division of Experimental Medicine, 1001 Potrero Ave., Building 3, Room 603, Box 1234, San Francisco, CA 94110. Phone: (415) 206-5518. Fax: (415) 206-5581. E-mail: douglas.nixon{at}ucsf.edu

{triangledown} Published ahead of print on 1 July 2009.

Clinical and Vaccine Immunology, September 2009, p. 1369-1371, Vol. 16, No. 9
1071-412X/09/$08.00+0     doi:10.1128/CVI.00410-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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