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Clinical and Vaccine Immunology, August 2009, p. 1256-1259, Vol. 16, No. 8
1071-412X/09/$08.00+0     doi:10.1128/CVI.00140-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Disappearance of Vaccine-Type Invasive Pneumococcal Disease and Emergence of Serotype 19A in a Minority Population with a High Prevalence of Human Immunodeficiency Virus and Low Childhood Immunization Rates{triangledown}

Azadeh Tasslimi,1 Erica J. Sison,2 Elizabeth Story,3 David Alland,3 Michele Burday,4 Susan Morrison,5 Sandhya Nalmas,6 Stephen Smith,7 Pauline A. Thomas,1 Peter Wenger,1 and Anushua Sinha1*

Department of Preventive Medicine and Community Health, New Jersey Medical School—UMDNJ, Newark, New Jersey,1 Department of Child and Family Well-Being, City of Newark, Newark, New Jersey,2 Center for the Study of Emerging and Reemerging Pathogens, New Jersey Medical School—UMDNJ, Newark, New Jersey,3 Department of Pathology, New Jersey Medical School—UMDNJ, Newark, New Jersey,4 Clara Maass Medical Center, Saint Barnabas Healthcare System, Belleville, New Jersey,5 Newark Beth Israel Medical Center, Saint Barnabas Healthcare System, Newark, New Jersey,6 Saint Michael's Medical Center, Catholic Health East, Newark, New Jersey7

Received 30 March 2009/ Returned for modification 6 May 2009/ Accepted 28 May 2009

We analyzed the epidemiology of invasive pneumococcal disease (IPD) following introduction of pneumococcal conjugated vaccine in an urban population with a 2% human immunodeficiency virus (HIV) prevalence and history of low childhood immunization rates. We observed near-elimination of vaccine-type IPD. Substantial disease remains due to non-vaccine-type pneumococci, highlighting the need to increase pneumococcal immunization among HIV-infected adults.

* Corresponding author. Mailing address: New Jersey Medical School—UMDNJ, MSB F594, 185 South Orange Avenue, Newark, NJ 07103. Phone: (973) 972-6538. Fax: (973) 972-7625. E-mail: sinhaan1{at}umdnj.edu

{triangledown} Published ahead of print on 10 June 2009.

Clinical and Vaccine Immunology, August 2009, p. 1256-1259, Vol. 16, No. 8
1071-412X/09/$08.00+0     doi:10.1128/CVI.00140-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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