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Clinical and Vaccine Immunology, August 2009, p. 1253-1255, Vol. 16, No. 8
1071-412X/09/$08.00+0     doi:10.1128/CVI.00149-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Evaluation of Helicobacter pylori Immunoglobulin G (IgG), IgA, and IgM Serologic Testing Compared to Stool Antigen Testing{triangledown}

Rosemary C. She,1,2* Andrew R. Wilson,2 and Christine M. Litwin1,2

Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah,1 Associated Regional University Pathologists Laboratories, Salt Lake City, Utah2

Received 1 April 2009/ Returned for modification 23 April 2009/ Accepted 29 May 2009

The utility of Helicobacter pylori serology was evaluated in 4,722 specimens and compared to stool antigen detection. Immunoglobulin M (IgM) sensitivity (6.8%) was unacceptably low. Key performance differences were observed in IgG specificity, IgA sensitivity, and specificity between adults and children that may warrant differentiating optimal serologic cutoff values by age.

* Corresponding author. Mailing address: 500 Chipeta Way, ARUP Laboratories, Salt Lake City, UT 84108. Phone: (801) 583-2787, ext. 3205. Fax: (801) 584-5207. E-mail: rosemary.she-bender{at}hsc.utah.edu

{triangledown} Published ahead of print on 10 June 2009.

Clinical and Vaccine Immunology, August 2009, p. 1253-1255, Vol. 16, No. 8
1071-412X/09/$08.00+0     doi:10.1128/CVI.00149-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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