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Clinical and Vaccine Immunology, August 2009, p. 1251-1252, Vol. 16, No. 8
1071-412X/09/$08.00+0     doi:10.1128/CVI.00376-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Age-Dependent Seroprevalence of Toscana Virus in Central Italy and Correlation with the Clinical Profile{triangledown}

C. Terrosi,1 R. Olivieri,2 C. Bianco,2 C. Cellesi,2 and M. G. Cusi1*

Microbiology Section,1 Infectious Diseases Section, Department of Molecular Biology, University of Siena, Policlinico S. Maria delle Scotte, Siena, Italy2

Received 13 October 2008/ Returned for modification 29 December 2008/ Accepted 10 June 2009

In order to estimate the antibody prevalence rates for Toscana virus (TOSV) among children and adults, we evaluated the seroprevalence of TOSV in a population (n = 2,737) living in Tuscany during the period of 1999 to 2006. The seroprevalence rate was 19.8% in adults and 5.8% in children, showing an age-dependent increase in TOSV-specific immunity. Meningitis due to TOSV infection was more frequent in adults than in children.

* Corresponding author. Mailing address: Department of Molecular Biology, Microbiology Section, University of Siena, Viale Bracci 1, 53100 Siena, Italy. Phone: 39 0577 233871. Fax: 39 0577 233870. E-mail: cusi{at}unisi.it

{triangledown} Published ahead of print on 24 June 2009.

Clinical and Vaccine Immunology, August 2009, p. 1251-1252, Vol. 16, No. 8
1071-412X/09/$08.00+0     doi:10.1128/CVI.00376-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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