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*Herpes Simplex

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Clinical and Vaccine Immunology, August 2009, p. 1247-1248, Vol. 16, No. 8
1071-412X/09/$08.00+0     doi:10.1128/CVI.00142-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Performance of the Epstein-Barr Virus and Herpes Simplex Virus Immunoglobulin M Assays on the Liaison Platform with Sera from Patients Displaying Acute Parvovirus B19 Infection{triangledown}

Elisa Costa, Nuria Tormo, María Ángeles Clari, Dayana Bravo, Beatriz Muñoz-Cobo, and David Navarro*

Service of Microbiology, Hospital Clínico Universitario, Valencia, Spain

Received 31 March 2009/ Returned for modification 8 June 2009/ Accepted 22 June 2009

Acute parvovirus B19 infection has been reported to cause false-positive results frequently in the Epstein-Barr (EBV) and herpes simplex virus (HSV) immunoglobulin M (IgM) assays from DiaSorin performed on the Liaison platform. We tested 65 sera from patients with a presumptive or conclusive diagnosis of acute parvovirus B19 infection in both assays and obtained no false-positive results in the EBV IgM test and 10.4% nonspecific reactivities in the HSV IgM assay. Our data support the specificity of both assays in this clinical setting.

* Corresponding author. Mailing address: Hospital Clínico Universitario, Av. Blasco Ibáñez 17, Valencia 46010, Spain. Phone: 34-96-38-64-657. Fax: 34-96-38-64-658. E-mail: David.Navarro{at}uv.es

{triangledown} Published ahead of print on 1 July 2009.

Clinical and Vaccine Immunology, August 2009, p. 1247-1248, Vol. 16, No. 8
1071-412X/09/$08.00+0     doi:10.1128/CVI.00142-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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