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Clinical and Vaccine Immunology, July 2009, p. 978-981, Vol. 16, No. 7
1071-412X/09/$08.00+0     doi:10.1128/CVI.00062-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Kinetics and Longevity of Antibody Response to Influenza A H5N1 Virus Infection in Humans{triangledown}

Rungrueng Kitphati,1 Phisanu Pooruk,2 Hatairat Lerdsamran,2 Siriwan Poosuwan,1 Suda Louisirirotchanakul,2 Prasert Auewarakul,2 Kulkanya Chokphaibulkit,3 Pirom Noisumdaeng,2 Pathom Sawanpanyalert,1 and Pilaipan Puthavathana2*

National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand,1 Department of Microbiology,2 Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand3

Received 9 February 2009/ Returned for modification 23 March 2009/ Accepted 11 May 2009

Anti-H5N1 antibody was determined by microneutralization, hemagglutination inhibition, and Western blotting assays in serial blood samples collected from eight Thai patients, including four fatal cases and four survivors. The antibody was detected as early as 5 days and, typically, with an increase in titer in paired blood at about 15 days after disease onset. The anti-H5 antibody response was long-lasting, for almost 5 years in cases which can be followed that far. In addition, cross-neutralizing activity to related clade 1 viruses was observed.

* Corresponding author. Mailing address: Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. Phone: 662-4197059. Fax: 662-4182663. E-mail: siput{at}mahidol.ac.th

{triangledown} Published ahead of print on 20 May 2009.

Clinical and Vaccine Immunology, July 2009, p. 978-981, Vol. 16, No. 7
1071-412X/09/$08.00+0     doi:10.1128/CVI.00062-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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