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Clinical and Vaccine Immunology, June 2009, p. 956-958, Vol. 16, No. 6
1071-412X/09/$08.00+0     doi:10.1128/CVI.00023-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Cellular and Humoral Responses to Leishmania major Virulence Factors in Healed Cutaneous Leishmaniasis and Mediterranean Visceral Leishmaniasis Patients{triangledown}

Inès Lakhal-Naouar, Thouraya Boussoffara, Amel Meddeb-Garnaoui, Yosser Ben Achour-Chenik, Hechmi Louzir, and Mehdi Chenik*

Laboratory of Immunopathology, Vaccinology, and Molecular Genetics, Institut Pasteur de Tunis, 13, Place Pasteur, 1002 Tunis-Belvedere, Tunisia

Received 16 January 2009/ Returned for modification 17 February 2009/ Accepted 23 March 2009

Cellular and humoral immune responses of healed cutaneous leishmaniasis and Mediterranean visceral leishmaniasis patients were evaluated against results for Leishmania major virulence proteins L. major protein disulfide isomerase (LmPDI) and mitogen-activated protein kinase kinase (MAPKK). Only MAPKK induces significant peripheral blood mononuclear cell proliferation with gamma interferon production as well as antibody responses. Thus, MAPKK may be of interest in Leishmania vaccination and serodiagnosis.

* Corresponding author. Mailing address: Institut Pasteur de Tunis, BP 74, 13, Place Pasteur, 1002 Tunis, Tunisia. Phone: 21671783022. Fax: 21671791833. E-mail: mehdi.chenik{at}pasteur.rns.tn

{triangledown} Published ahead of print on 1 April 2009.

Clinical and Vaccine Immunology, June 2009, p. 956-958, Vol. 16, No. 6
1071-412X/09/$08.00+0     doi:10.1128/CVI.00023-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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