This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lakhal-Naouar, I.
Right arrow Articles by Chenik, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lakhal-Naouar, I.
Right arrow Articles by Chenik, M.

 Previous Article  |  Next Article 

Clinical and Vaccine Immunology, June 2009, p. 956-958, Vol. 16, No. 6
1071-412X/09/$08.00+0     doi:10.1128/CVI.00023-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Cellular and Humoral Responses to Leishmania major Virulence Factors in Healed Cutaneous Leishmaniasis and Mediterranean Visceral Leishmaniasis Patients{triangledown}

Inès Lakhal-Naouar, Thouraya Boussoffara, Amel Meddeb-Garnaoui, Yosser Ben Achour-Chenik, Hechmi Louzir, and Mehdi Chenik*

Laboratory of Immunopathology, Vaccinology, and Molecular Genetics, Institut Pasteur de Tunis, 13, Place Pasteur, 1002 Tunis-Belvedere, Tunisia

Received 16 January 2009/ Returned for modification 17 February 2009/ Accepted 23 March 2009

Cellular and humoral immune responses of healed cutaneous leishmaniasis and Mediterranean visceral leishmaniasis patients were evaluated against results for Leishmania major virulence proteins L. major protein disulfide isomerase (LmPDI) and mitogen-activated protein kinase kinase (MAPKK). Only MAPKK induces significant peripheral blood mononuclear cell proliferation with gamma interferon production as well as antibody responses. Thus, MAPKK may be of interest in Leishmania vaccination and serodiagnosis.

* Corresponding author. Mailing address: Institut Pasteur de Tunis, BP 74, 13, Place Pasteur, 1002 Tunis, Tunisia. Phone: 21671783022. Fax: 21671791833. E-mail: mehdi.chenik{at}pasteur.rns.tn

{triangledown} Published ahead of print on 1 April 2009.

Clinical and Vaccine Immunology, June 2009, p. 956-958, Vol. 16, No. 6
1071-412X/09/$08.00+0     doi:10.1128/CVI.00023-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»