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Clinical and Vaccine Immunology, June 2009, p. 953-955, Vol. 16, No. 6
1071-412X/09/$08.00+0     doi:10.1128/CVI.00071-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Altered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosis{triangledown}

Camila R. Cacere,1 Maria J. S. Mendes-Giannini,2 Antonio Carlos F. do Valle,3 Alberto J. S. Duarte,1 and Gil Benard1,4*

Laboratory of Dermatology and Immunodeficiencies, Medical School of the University of São Paulo, São Paulo, Brazil,1 Clinical Pathology Department, Faculty of Pharmaceutical Sciences, São Paulo State University, Araraquara, São Paulo, Brazil,2 Instituto de Pesquisa Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil,3 Systemic Mycoses Outpatient Unit, Division of Infectious Diseases, Clinics Hospital, Medical School of the University of São Paulo, São Paulo, Brazil4

Received 18 February 2009/ Returned for modification 9 April 2009/ Accepted 16 April 2009

To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis.

* Corresponding author. Mailing address: Laboratory of Dermatology and Immunodeficiencies (LIM-56), Medical School of the University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar 500, 3rd Floor, São Paulo 05403-903, Brazil. Phone: 55 11 30617499. Fax: 55 11 30817190. E-mail: mahong{at}usp.br

{triangledown} Published ahead of print on 22 April 2009.

Clinical and Vaccine Immunology, June 2009, p. 953-955, Vol. 16, No. 6
1071-412X/09/$08.00+0     doi:10.1128/CVI.00071-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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