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Clinical and Vaccine Immunology, May 2009, p. 775-778, Vol. 16, No. 5
1071-412X/09/$08.00+0     doi:10.1128/CVI.00432-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Potential Use of the Hemagglutinin-Neuraminidase Glycoprotein of Newcastle Disease Virus Expressed in Rachiplusia nu Larvae as an Immunogen for Chickens{triangledown}

Silvina Chimeno Zoth,1,2 Evangelina Gómez,1,2 Juan Manuel Carballeda,1 Oscar Taboga,1,2 Elisa Carrillo,1,2 and Analía Berinstein1,2*

Instituto de Biotecnología, CICVyA, INTA, Castelar, Cc 25 B1712WAA, Buenos Aires, Argentina,1 Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Rivadavia 1917 C1033AAJ, Ciudad de Buenos Aires, Argentina2

Received 20 November 2008/ Returned for modification 11 December 2008/ Accepted 6 March 2009

The hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus (NDV) was obtained as a recombinant antigen in Rachiplusia nu larvae. When it was used as an immunogen in chickens, a solid immune response, including neutralizing antibodies, was detected, demonstrating the potential use of this simple and economic strategy in the design of recombinant anti-NDV vaccines.

* Corresponding author. Mailing address: Instituto de Biotecnología, CICVyA, INTA, Castelar, Cc 25 B1712WAA, Buenos Aires, Argentina. Phone: 54-11-4621-1278. Fax: 54-11-4621-0199. E-mail: aberinstein{at}cnia.inta.gov.ar

{triangledown} Published ahead of print on 18 March 2009.

Clinical and Vaccine Immunology, May 2009, p. 775-778, Vol. 16, No. 5
1071-412X/09/$08.00+0     doi:10.1128/CVI.00432-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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