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Clinical and Vaccine Immunology, May 2009, p. 772-774, Vol. 16, No. 5
1071-412X/09/$08.00+0     doi:10.1128/CVI.00438-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Good Performance of Immunoglobulin M Assays in Diagnosing Genotype 3 Hepatitis E Virus Infections{triangledown}

Florence Legrand-Abravanel,1,2 Isabelle Thevenet,2 Jean-Michel Mansuy,2 Karine Saune,1,2 Françoise Vischi,2 Jean-Marie Peron,3 Nassim Kamar,4 Lionel Rostaing,1,4 and Jacques Izopet1,2*

INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse F-31300, France,1 CHU Toulouse, Hôpital Purpan, Laboratoire de Virologie, Institut Fédératif de Biologie de Purpan, Toulouse F-31300, France,2 CHU Toulouse, Hôpital Purpan, Département de Gastroentérologie, Toulouse F-31300, France,3 CHU Toulouse, Hôpital Rangueil, Département de Nephrologie, Dialyse et Transplantation Multi-Organe, Toulouse F-31300, France4

Received 14 November 2008/ Returned for modification 13 January 2009/ Accepted 13 March 2009

We have evaluated three anti-hepatitis E virus (anti-HEV) immunoglobulin M (IgM) assays, the EIAgen HEV IgM assay (Adaltis), the HEV IgM enzyme-linked immunosorbent assay 3.0, and the Assure HEV IgM rapid test (MP Diagnostics), for the routine detection of acute genotype 3 HEV. Their sensitivities were fairly good (90%, 88%, and 82%), and their specificities were excellent (100%, 99.5%, and 100%).

* Corresponding author. Mailing address: Laboratoire de Virologie, Institut Fédératif de Biologie, TSA 40031, CHU Toulouse Purpan, 31059 Toulouse Cedex, France. Phone: (33) 5 67 69 04 24. Fax: (33) 5 67 69 04 25. E-mail: izopet.j{at}chu-toulouse.fr

{triangledown} Published ahead of print on 25 March 2009.

Clinical and Vaccine Immunology, May 2009, p. 772-774, Vol. 16, No. 5
1071-412X/09/$08.00+0     doi:10.1128/CVI.00438-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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