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Clinical and Vaccine Immunology, April 2009, p. 592-593, Vol. 16, No. 4
1071-412X/09/$08.00+0     doi:10.1128/CVI.00207-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Evaluation of Antibodies against Different Epstein-Barr Virus Nuclear Antigen 1 Peptides in Diagnosis of Nasopharyngeal Carcinoma{triangledown}

Ai-Di Gu,1,2 Hao-Yuan Mo,3 Jin-Xin Bei,1,2 Yan-Bo Xie,1,2 Li-Zhen Chen,1,2 Qi-Sheng Feng,1,2 Tiebang Kang,1,2 and Yi-Xin Zeng1,2*

State Key Laboratory of Oncology in Southern China,1 Departments of Experimental Research,2 Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China3

Received 28 May 2008/ Returned for modification 22 August 2008/ Accepted 9 February 2009

Epstein-Barr virus nuclear antigen 1 (EBNA1) is a protein expressed consistently in nasopharyngeal carcinoma (NPC). Although antibody levels against three different EBNA1 peptides were all high in NPC patients, the correlation between any two biomarkers was low. Therefore, the selection of distinct EBNA1 peptides could render different results in serological detection for individuals with NPC.

* Corresponding author. Mailing address: Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, China. Phone: 86-20-8734-3333. Fax: 86-20-8734-3295. E-mail: zengyix{at}mail.sysu.edu.cn

{triangledown} Published ahead of print on 11 March 2009.

Clinical and Vaccine Immunology, April 2009, p. 592-593, Vol. 16, No. 4
1071-412X/09/$08.00+0     doi:10.1128/CVI.00207-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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