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Clinical and Vaccine Immunology, April 2009, p. 587-588, Vol. 16, No. 4
1071-412X/09/$08.00+0     doi:10.1128/CVI.00462-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Frequency of Missed Cases of Probable Acute West Nile Virus (WNV) Infection when Testing for WNV RNA Alone or WNV Immunoglobulin M Alone{triangledown}

Harry E. Prince,* Jan Calma, Tiffany Pham, and Brent L. Seaton

Focus Diagnostics, Inc., Cypress, California 90630

Received 8 December 2008/ Returned for modification 11 January 2009/ Accepted 9 February 2009

To estimate the frequency of missed cases of acute West Nile virus (WNV) infection if only WNV RNA or immunoglobulin M (IgM) testing is requested, we measured IgM in specimens negative for RNA and vice versa. Whereas 6 (5.5%) of 110 RNA-negative sera were IgM positive, only 3 (1.0%) of 299 IgM-negative sera were RNA positive (P < 0.05). Similarly, 11 (7.8%) of 141 RNA-negative cerebrospinal fluid specimens (CSF) were IgM positive, but 0 (0%) of 118 IgM-negative CSF were RNA positive (P < 0.05). WNV infections may be missed if only RNA or IgM testing is requested, with a higher frequency of missed cases if only RNA testing is requested.

* Corresponding author. Mailing address: Focus Diagnostics, Inc., 5785 Corporate Avenue, Cypress, CA 90630. Phone: (714) 822-2457. Fax: (714) 821-3364. E-mail: hprince{at}focusdx.com

{triangledown} Published ahead of print on 18 February 2009.

Clinical and Vaccine Immunology, April 2009, p. 587-588, Vol. 16, No. 4
1071-412X/09/$08.00+0     doi:10.1128/CVI.00462-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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