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Clinical and Vaccine Immunology, March 2009, p. 430-432, Vol. 16, No. 3
1071-412X/09/$08.00+0     doi:10.1128/CVI.00480-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Efficacy of a Genetically Engineered Candida albicans tet-NRG1 Strain as an Experimental Live Attenuated Vaccine against Hematogenously Disseminated Candidiasis{triangledown}

Stephen P. Saville,1 Anna L. Lazzell,1 Ashok K. Chaturvedi,1 Carlos Monteagudo,2 and Jose L. Lopez-Ribot1*

Department of Biology and South Texas Center for Emerging Infectious Diseases, the University of Texas at San Antonio, San Antonio, Texas,1 Departamento de Patología, Facultad de Medicina y Odontología, Universidad de Valencia, Valencia, Spain2

Received 19 December 2008/ Accepted 30 December 2008

We report on the efficacy of the genetically engineered Candida albicans tet-NRG1 strain as an experimental live, attenuated vaccine against disseminated candidiasis in both immunocompetent and immunodeficient mice mostly dependent on T-cell immunity. This experimental vaccination model may represent an important tool to unravel the mechanisms of protective immunity during candidiasis.

* Corresponding author. Mailing address: Dept. of Biology, the University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249. Phone: (210) 458-7022. Fax: (210) 458-7023. E-mail: jose.lopezribot{at}utsa.edu

{triangledown} Published ahead of print on 14 January 2009.

Clinical and Vaccine Immunology, March 2009, p. 430-432, Vol. 16, No. 3
1071-412X/09/$08.00+0     doi:10.1128/CVI.00480-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Xue, J., Chen, X., Selby, D., Hung, C.-Y., Yu, J.-J., Cole, G. T. (2009). A Genetically Engineered Live Attenuated Vaccine of Coccidioides posadasii Protects BALB/c Mice against Coccidioidomycosis. Infect. Immun. 77: 3196-3208 [Abstract] [Full Text]  


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