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Clinical and Vaccine Immunology, March 2009, p. 427-429, Vol. 16, No. 3
1071-412X/09/$08.00+0     doi:10.1128/CVI.00396-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Safety and Immunogenicity of the Mycobacterium tuberculosis {Delta}lysA {Delta}panCD Vaccine in Domestic Cats Infected with Feline Immunodeficiency Virus{triangledown}

Dawn M. Zimmerman,1* W. Ray Waters,2 Konstantin P. Lyashchenko,3 Brian J. Nonnecke,2 Douglas L. Armstrong,4 William R. Jacobs Jr.,5 Michelle H. Larsen,5 Erin Egan,6 and Gregg A. Dean6

Memphis Zoo and Aquarium, Memphis, Tennessee,1 National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa,2 Chembio Diagnostic Systems, Inc., Medford, New York,3 Henry Doorly Zoo, Omaha, Nebraska,4 Howard Hughes Medical Institute and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461,5 Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina6

Received 30 October 2008/ Returned for modification 1 December 2008/ Accepted 7 January 2009

Feline immunodeficiency virus (FIV)-positive and FIV-negative cats (n = 4/group) received 2 x 106 CFU Mycobacterium tuberculosis {Delta}lysA {Delta}panCD intramuscularly. Vaccination elicited antibody responses, albeit at lower levels in FIV-positive cats than in FIV-negative cats. Delayed-type hypersensitivity responses were minimal in both groups. No adverse reactions were found.

* Corresponding author. Mailing address: Memphis Zoo and Aquarium, 2000 Prentiss Place, Memphis, TN 38112. Phone: (901) 331-6641. Fax: (901) 333-6505. E-mail: dzimmerman{at}memphiszoo.org

{triangledown} Published ahead of print on 14 January 2009.

Clinical and Vaccine Immunology, March 2009, p. 427-429, Vol. 16, No. 3
1071-412X/09/$08.00+0     doi:10.1128/CVI.00396-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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