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Clinical and Vaccine Immunology, February 2009, p. 288-290, Vol. 16, No. 2
1071-412X/09/$08.00+0     doi:10.1128/CVI.00281-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Enzyme-Linked Immunosorbent Assay Method for Detection of Cytomegalovirus Strain-Specific Antibody Responses{triangledown}

Zdenek Novak,1* Shannon A. Ross,1 Raj Kumar Patro,2 Sunil Kumar Pati,2 Meera K. Reddy,1 Misty Purser,1 William J. Britt,1 and Suresh B. Boppana1

Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama,1 All India Institute of Medical Sciences, New Delhi, India2

Received 30 July 2008/ Returned for modification 22 September 2008/ Accepted 17 November 2008

Reliable methods for the detection of cytomegalovirus (CMV) strain-specific serological responses are lacking. We describe a simple and reliable enzyme-linked immunosorbent assay method developed to detect antibodies against the polymorphic epitopes within the two envelope glycoproteins of CMV, glycoproteins H and B. This assay is useful for the detection of serologic responses to CMV strains and the identification of CMV reinfections.

* Corresponding author. Mailing address: University of Alabama at Birmingham, Children's Hospital, CHB 150, 1600 6th Ave. S., Birmingham, AL 35233. Phone: (205) 996-7896. Fax: (205) 996-7150. E-mail: zdnovak{at}peds.uab.edu

{triangledown} Published ahead of print on 26 November 2008.

Clinical and Vaccine Immunology, February 2009, p. 288-290, Vol. 16, No. 2
1071-412X/09/$08.00+0     doi:10.1128/CVI.00281-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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