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Clinical and Vaccine Immunology, February 2009, p. 282-284, Vol. 16, No. 2
1071-412X/09/$08.00+0     doi:10.1128/CVI.00305-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Development of an Immunoglobulin M Capture-Based Enzyme-Linked Immunosorbent Assay for Diagnosis of Acute Infections with Bartonella henselae{triangledown}

John G. Hoey,1* Fernando Valois-Cruz,1 Hannah Goldenberg,1 Yekaterina Voskoboynik,1 Jenna Pfiffner,1 Richard C. Tilton,2 Eli Mordechai,2 and Martin E. Adelson2

Antigen Discovery Division, Research and Development Department,1 Research and Development Department, Medical Diagnostic Laboratories, Hamilton, New Jersey 086902

Received 24 August 2008/ Returned for modification 1 October 2008/ Accepted 20 November 2008

We describe the development of an immunoglobulin M-specific enzyme-linked immunosorbent assay for the detection of an early antibody response to Bartonella henselae, the causative agent of cat scratch disease, bacillary angiomatosis, and endocarditis. This assay discriminates between B. henselae-positive and -negative patient samples with sensitivity and specificity values of 100% and 97.1%, respectively.

* Corresponding author. Mailing address: Antigen Discovery Division Head, Medical Diagnostic Laboratories, LLC, 2439 Kuser Road, Hamilton, NJ 08690-3303. Phone: (609) 570-1015. Fax: (609) 570-1030. E-mail: jhoey{at}mdlab.com

{triangledown} Published ahead of print on 3 December 2008.

Clinical and Vaccine Immunology, February 2009, p. 282-284, Vol. 16, No. 2
1071-412X/09/$08.00+0     doi:10.1128/CVI.00305-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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