This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by George, M. D.
Right arrow Articles by Dandekar, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by George, M. D.
Right arrow Articles by Dandekar, S.

 Previous Article  |  Next Article 

Clinical and Vaccine Immunology, February 2009, p. 277-281, Vol. 16, No. 2
1071-412X/09/$08.00+0     doi:10.1128/CVI.00265-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Heightened Cytotoxic Responses and Impaired Biogenesis Contribute to Early Pathogenesis in the Oral Mucosa of Simian Immunodeficiency Virus-Infected Rhesus Macaques{triangledown}

Michael D. George,* David Verhoeven, Sumathi Sankaran, Tiffany Glavan, Elizabeth Reay, and Satya Dandekar

Department of Medical Microbiology, School of Medicine, University of California, Davis, California 95616

Received 11 July 2008/ Returned for modification 25 September 2008/ Accepted 5 December 2008

Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4+ T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, University of California, Davis, Room 3318 Tupper Hall, One Shields Ave., Davis, CA 95616. Phone: (530) 752-7207. Fax: (530) 754-7242. E-mail: mdgeorge{at}ucdavis.edu

{triangledown} Published ahead of print on 17 December 2008.

Clinical and Vaccine Immunology, February 2009, p. 277-281, Vol. 16, No. 2
1071-412X/09/$08.00+0     doi:10.1128/CVI.00265-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»