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Clinical and Vaccine Immunology, February 2009, p. 246-252, Vol. 16, No. 2
1071-412X/09/$08.00+0     doi:10.1128/CVI.00023-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Anti-Polyribosylribitol Phosphate Antibody Concentrations and Avidities in Children since the Start of Haemophilus influenzae Type b Immunization of Infants in the United Kingdom{triangledown}

Dominic F. Kelly,1* E. Richard Moxon,1 Ly-Mee Yu,2 and Andrew J. Pollard1

Oxford Vaccine Group, Oxford University Department of Paediatrics,1 Centre for Statistics in Medicine, Oxford, United Kingdom2

Received 19 January 2008/ Returned for modification 13 February 2008/ Accepted 3 September 2008

The introduction of routine infant immunization with Haemophilus influenzae type b (Hib) conjugate vaccines in the United Kingdom in 1992 led to a significant reduction in invasive disease due to this organism. Subsequently, between 1999 and 2003 there was an increase in the number of immunized children with Hib infection. We investigated whether the rise in cases was related to changes in anti-polyribosylribitol phosphate (PRP) antibody concentration or avidity. Using stored sera, we analyzed temporal changes in antibody levels among 3- to 5-year-old children immunized between 1991 and 2000. Anti-PRP antibody concentrations were higher in 3- to 5-year-olds who received infant immunization in 1991 than those in subsequent years. This difference may be related to changes in either the mode of administration of Hib conjugate vaccines or the rates of Hib nasopharyngeal carriage. This study emphasizes the factors affecting anti-PRP antibody concentration following immunization with conjugate vaccines and the importance of these in long-term protection from invasive disease.

* Corresponding author. Mailing address: Oxford University Department of Paediatrics, Level 2, Room 02-46-03, Children's Hospital, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom. Phone: 44 (0)1865 234240. Fax: 44 (0)1865 234242. E-mail: dominic.kelly{at}paediatrics.ox.ac.uk

{triangledown} Published ahead of print on 10 September 2008.

Clinical and Vaccine Immunology, February 2009, p. 246-252, Vol. 16, No. 2
1071-412X/09/$08.00+0     doi:10.1128/CVI.00023-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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