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Clinical and Vaccine Immunology, February 2009, p. 230-232, Vol. 16, No. 2
1071-412X/09/$08.00+0     doi:10.1128/CVI.00367-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Protection against Asiatic Taenia solium Induced by a Recombinant 45W-4B Protein{triangledown}

Xuenong Luo, Yadong Zheng,{dagger} Junling Hou, Shaohua Zhang, and Xuepeng Cai*

Key Laboratory of Zoonoses of CAAS, Key Laboratory of Veterinary Parasitology of Gansu Province, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu, China

Received 8 October 2008/ Returned for modification 6 November 2008/ Accepted 9 December 2008

Taenia solium is a great threat not only to human health but also to the pig-raising industry. Oncospheral stage-specific 45W proteins are good candidates for the development of anticysticercosis vaccines. In this study, a recombinant 45W-4B protein was highly produced and used for vaccination. Two animal trials resulted in a significant reduction in parasite burden induced by the definite protein against Asiatic T. solium, up to 97.0% and 98.4%, respectively. These provide informative results for the development of effective 45W-4B vaccines against cysticercosis caused by both Chinese and Mexican T. solium isolates and even by other isolates.

* Corresponding author. Mailing address: Lanzhou Veterinary Research Institute, CAAS, Xujiaping 1, Yanchangbu, Lanzhou 730046, Gansu, China. Phone: 86 931 8342535. Fax: 86 931 8340977. E-mail: zhyd9{at}hotmail.com

{triangledown} Published ahead of print on 17 December 2008.

{dagger} Present address: School of Biology, the University of Nottingham, Nottingham NG7 2AY, United Kingdom.

Clinical and Vaccine Immunology, February 2009, p. 230-232, Vol. 16, No. 2
1071-412X/09/$08.00+0     doi:10.1128/CVI.00367-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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