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Clinical and Vaccine Immunology, November 2009, p. 1696-1699, Vol. 16, No. 11
1071-412X/09/$08.00+0     doi:10.1128/CVI.00173-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Recombinant Sindbis Virus Vectors Designed To Express Protective Antigen of Bacillus anthracis Protect Animals from Anthrax and Display Synergy with Ciprofloxacin{triangledown}

John M. Thomas,1* Scott T. Moen,1 Bryan T. Gnade,1 Diego A. Vargas-Inchaustegui,1 Sheri M. Foltz,1 Giovanni Suarez,1 Hans W. Heidner,2 Rolf König,1,3 Ashok K. Chopra,1,3,4 and Johnny W. Peterson1,3,4

Department of Microbiology and Immunology,1 Sealy Center for Vaccine Development,3 Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas 77555-1070,4 University of Texas at San Antonio, Department of Biology, San Antonio, Texas 782492

Received 23 April 2009/ Returned for modification 9 July 2009/ Accepted 2 September 2009

Recombinant Sindbis viruses were engineered to express alternative forms of the protective antigen (PA) of Bacillus anthracis. The recombinant viruses induced PA-specific immunoglobulin G and neutralizing antibodies in Swiss Webster mice. Vaccination with the recombinant viruses induced immunity that offered some protection from a lethal Ames strain spore challenge and synergized the protective effects of ciprofloxacin.

* Corresponding author. Present address: Department of Pharmacology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390. Phone: (214) 648-1809. Fax: (214) 648-1613. E-mail: JohnM.Thomas{at}utsouthwestern.edu

{triangledown} Published ahead of print on 16 September 2009.

Clinical and Vaccine Immunology, November 2009, p. 1696-1699, Vol. 16, No. 11
1071-412X/09/$08.00+0     doi:10.1128/CVI.00173-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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