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Clinical and Vaccine Immunology, November 2009, p. 1693-1695, Vol. 16, No. 11
1071-412X/09/$08.00+0     doi:10.1128/CVI.00125-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Investigation on the Effect of Immune Selection on Resistance to Bactericidal Antibodies to Group B Meningococci In Vitro{triangledown}

George F. Santos,1* Marzia Giuliani,2 Laura Santini,2 Jeanette Adu-Bobie,2 Mariagrazia Pizza,2 Rino Rappuoli,2 William Wacknov,3 and John Donnelly2

Novartis Vaccines, 350 Massachusetts Ave., Cambridge, Massachusetts 02139,1 Novartis Vaccines, Via Fiorentina 1, 53100 Siena, Italy,2 Novartis Vaccines, 4560 Horton St., Emeryville, California 946083

Received 12 March 2009/ Returned for modification 12 June 2009/ Accepted 19 August 2009

The induction of resistance by immune selective pressure to bactericidal antibodies from humans immunized with Novartis recombinant meningococcal group B vaccines was assessed. Serum bactericidal antibody titers against selected bacteria were within assay variability through a selection event frequency of 1 in 10–5. No change in antigen expression was observed by Western blotting.

* Corresponding author. Mailing address: Novartis Vaccines, 350 Mass Ave., Cambridge, MA 02139. Phone: (617) 871-8187. Fax: (617) 871-5135. E-mail: george.santos{at}novartis.com

{triangledown} Published ahead of print on 26 August 2009.

Clinical and Vaccine Immunology, November 2009, p. 1693-1695, Vol. 16, No. 11
1071-412X/09/$08.00+0     doi:10.1128/CVI.00125-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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