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Clinical and Vaccine Immunology, October 2009, p. 1527-1528, Vol. 16, No. 10
1071-412X/09/$08.00+0     doi:10.1128/CVI.00183-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Kinetic Patterns of Candida albicans Germ Tube Antibody in Critically Ill Patients: Influence on Mortality{triangledown}

Rafael Zaragoza,1* Javier Pemán,3 Guillermo Quindós,5 Jose R. Iruretagoyena,6 María S. Cuétara,7 Paula Ramírez,4 Maria D. Gómez,3 Juan J. Camarena,2 Angel Viudes,3 José Pontón,5 on behalf of the Candida albicans Germ Tube Antibody Detection in Critically Ill Patients (CAGTAUCI) Study Group{dagger}

Intensive Care Unit,1 Department of Microbiology, Hospital Universitario Dr. Peset, Valencia, Spain,2 Department of Microbiology,3 Intensive Care Unit, Hospital Universitario La Fe, Valencia, Spain,4 Universidad del País Vasco, Bilbao, Spain,5 Intensive Care Unit, Hospital Universitario Cruces, Barakaldo, Spain,6 Department of Microbiology Hospital Severo Ochoa, Leganés, Spain7

Received 6 May 2009/ Accepted 28 July 2009

The influence of kinetic patterns of Candida albicans germ tube antibodies (CAGTA) on mortality was analyzed in six intensive care units. Statistically significant lower mortality rates were found in patients with patterns of increasing CAGTA titers who had been treated with antifungal agents. Thus, antifungal treatment should be considered when CAGTA titers are increasing in critically ill patients.

* Corresponding author. Mailing address: Intensive Care Unit, Hospital Universitario Dr. Peset, Avda Gaspar Aguilar, 90 46017 Valencia, Spain. Phone: 34 96 3862526. Fax: 34 96 3861933. E-mail: zaragozar{at}ono.com

{triangledown} Published ahead of print on 12 August 2009.

{dagger} Members of the CAGTAUCI Study Group are listed in Acknowledgments.

Clinical and Vaccine Immunology, October 2009, p. 1527-1528, Vol. 16, No. 10
1071-412X/09/$08.00+0     doi:10.1128/CVI.00183-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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