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Clinical and Vaccine Immunology, October 2009, p. 1524-1526, Vol. 16, No. 10
1071-412X/09/$08.00+0     doi:10.1128/CVI.00276-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Clinical Evaluation of a (1,3)-β-D-Glucan Assay for Presumptive Diagnosis of Pneumocystis jiroveci Pneumonia in Immunocompromised Patients{triangledown}

Valerio Del Bono,1* Alessandra Mularoni,1 Elisa Furfaro,1 Emanuele Delfino,1 Lorenzo Rosasco,2 Franca Miletich,1 and Claudio Viscoli1

Clinica Malattie Infettive, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy,1 DISI, Università di Genova, Genoa, Italy2

Received 29 June 2009/ Returned for modification 11 August 2009/ Accepted 13 August 2009

(1,3)-β-D-Glucan (BG) is a component of the Pneumocystis jiroveci cell wall. Thirty-one immunocompromised patients with pneumonia (16 with presumptive pneumocystis pneumonia [PCP] and 15 with non-PCP) were evaluated for serum BG levels. Serum from all 16 presumptive PCP patients and from 2/15 patients with non-PCP was positive for BG. Results indicate that BG is a reliable marker for diagnosing PCP.

* Corresponding author. Mailing address: Clinica Malattie Infettive, Azienda Ospedaliera Universitaria San Martino, Largo R. Benzi 10, 16132 Genoa, Italy. Phone: 0039-348-6954003. Fax: 0039-010-555-6712. E-mail: valerio.delbono{at}hsanmartino.it

{triangledown} Published ahead of print on 19 August 2009.

Clinical and Vaccine Immunology, October 2009, p. 1524-1526, Vol. 16, No. 10
1071-412X/09/$08.00+0     doi:10.1128/CVI.00276-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • del Palacio, A., Cuetara, M. S., Llenas-Garcia, J., Alvarez, M. E., Chaves, F., Pulido, F., Catalan, M., Ponton, J., Del Bono, V., Viscoli, C. (2010). Serum (1->3)-{beta}-D-Glucan Assay for the Diagnosis of Pneumocystis jiroveci Pneumonia. CVI 17: 202-203 [Full Text]  


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