This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by López-Álvarez, M. R.
Right arrow Articles by Minguela, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by López-Álvarez, M. R.
Right arrow Articles by Minguela, A.

 Previous Article

Clinical and Vaccine Immunology, January 2009, p. 142-145, Vol. 16, No. 1
1071-412X/09/$08.00+0     doi:10.1128/CVI.00358-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Association of Monoclonal Expansion of Epstein-Barr Virus-Negative CD158a+ NK Cells Secreting Large Amounts of Gamma Interferon with Hemophagocytic Lymphohistiocytosis{triangledown}

María R. López-Álvarez,1,6 María V. Martínez-Sánchez,1 María G. Salgado-Cecilia,1 José A. Campillo,1,6 Damian Heine-Suñer,2 Florentina Villar-Permuy,1 José L. Fuster,3 Águeda Bas,4 Juana Gil-Herrera,5 Manuel Muro,1,6 Ana M. García-Alonso,1,6 María R. Álvarez-López,1,6 and Alfredo Minguela1,6*

Inmunology,1 Pediatric Oncology,3 Pathology Services, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain,4 Molecular Genetics, Hospital Universitario Son Dureta, Palma de Mallorca, Spain,2 Inmunology Service, Hospital Gregorio Marañón, Madrid, Spain,5 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Spain6

Received 30 September 2008/ Returned for modification 7 November 2008/ Accepted 13 November 2008

ABSTRACT

We report the first case of hemophagocytic lymphohistiocytosis (HLH) induced by the monoclonal expansion of Epstein-Barr virus (EBV)-negative NK cells. Consanguinity of the patient's parents made it necessary to discard familial HLH in the patient and her sister with identical HLA markers and demonstrate that no cause other than the expansion of NK cells, which secrete high levels of gamma interferon, was inducing HLH in this patient.

* Corresponding author. Mailing address: Servicio de Inmunología, Hospital Universitario Virgen de la Arrixaca, El Palmar, 30120 Murcia, Spain. Phone: (34) 968 395379. Fax: (34) 968 369029. E-mail: alfredo.minguela{at}carm.es

FOOTNOTES

{triangledown} Published ahead of print on 19 November 2008.

{dagger}https://www.ciberehd.org/.

Clinical and Vaccine Immunology, January 2009, p. 142-145, Vol. 16, No. 1
1071-412X/09/$08.00+0     doi:10.1128/CVI.00358-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»