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Clinical and Vaccine Immunology, January 2009, p. 139-141, Vol. 16, No. 1
1071-412X/09/$08.00+0     doi:10.1128/CVI.00360-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Pediatric Antibody Response to Community-Acquired Staphylococcus aureus Infection Is Directed to Panton-Valentine Leukocidin{triangledown}

Eric L. Brown,1* M. Gabriela Bowden,2 Rebecca S. Bryson,1 Kristina G. Hulten,3 Andrea S. Bordt,2 Andrea Forbes,3 and Sheldon L. Kaplan3

Center for Infectious Disease, University of Texas School of Public Health, Houston, Texas,1 Center for Extracellular Matrix Biology, Texas A&M University Institute of Biosciences and Technology, Houston, Texas,2 Department of Pediatrics, Baylor College of Medicine, and the Texas Children's Hospital, Houston, Texas3

Received 26 September 2008/ Returned for modification 24 October 2008/ Accepted 3 November 2008

We examined the antibody responses of pediatric patients infected with community-associated Staphylococcus aureus isolates. The data show that patients infected with Panton-Valentine leukocidin (PVL)-positive strains developed a dominant immunoglobulin G anti-PVL antibody response that correlates with markers of inflammation.

* Corresponding author. Mailing address: Center for Infectious Disease, University of Texas School of Public Health, 1200 Herman-Pressler Dr., Houston, TX 77030. Phone: (713) 500-9355. Fax: (713) 500-9359. E-mail: eric.l.brown{at}uth.tmc.edu

{triangledown} Published ahead of print on 12 November 2008.

Clinical and Vaccine Immunology, January 2009, p. 139-141, Vol. 16, No. 1
1071-412X/09/$08.00+0     doi:10.1128/CVI.00360-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yoong, P., Pier, G. B. (2010). Antibody-mediated enhancement of community-acquired methicillin-resistant Staphylococcus aureus infection. Proc. Natl. Acad. Sci. USA 107: 2241-2246 [Abstract] [Full Text]  


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