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Clinical and Vaccine Immunology, January 2009, p. 134-135, Vol. 16, No. 1
1071-412X/09/$08.00+0     doi:10.1128/CVI.00220-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Use of a Surrogate Chimeric Virus To Detect West Nile Virus-Neutralizing Antibodies in Avian and Equine Sera{triangledown}

Nicholas Komar,1* Stanley Langevin,1 and Thomas P. Monath2,{dagger}

Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, Colorado,1 Acambis, Incorporated, Cambridge, Massachusetts2

Received 11 June 2008/ Returned for modification 7 July 2008/ Accepted 3 November 2008

A chimeric yellow fever virus/West Nile virus (WNV) was compared to WNV alone as a biosafety level 2 reagent in the plaque reduction neutralization test for determining WNV infection histories. Concordance was 96.3% among 188 avian and equine serum samples. Neutralizing antibody titers were frequently more than twofold lower with the chimera.

* Corresponding author. Mailing address: CDC-NCZVED-DVBID-ADB, 3150 Rampart Rd., Fort Collins, CO 80521. Phone: (970) 221-6496. Fax: (970) 221-6476. E-mail: nkomar{at}cdc.gov

{triangledown} Published ahead of print on 12 November 2008.

{dagger} Present address: Kleiner Perkins Caufield and Byers, Menlo Park, CA.

Clinical and Vaccine Immunology, January 2009, p. 134-135, Vol. 16, No. 1
1071-412X/09/$08.00+0     doi:10.1128/CVI.00220-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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