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*Dengue

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Clinical and Vaccine Immunology, August 2008, p. 1304-1306, Vol. 15, No. 8
1071-412X/08/$08.00+0     doi:10.1128/CVI.00157-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Development of a More Efficient Algorithm for Identifying False-Positive Reactivity Results in a Dengue Virus Immunoglobulin M Screening Assay {triangledown}

Harry E. Prince,* Cindy Yeh, and Mary Lapé-Nixon

Focus Diagnostics Inc., Cypress, California

Received 2 May 2008/ Returned for modification 29 May 2008/ Accepted 9 June 2008

Of 2,692 sera screened for dengue virus immunoglobulin M by using a µ-capture enzyme-linked immunosorbent assay (ELISA), 954 had equivocal (index from 0.90 to 1.10) or positive (index of >1.10) results and were retested using a background subtraction (BS) ELISA that identifies screen false positives. No false positives were found among 427 sera with screen ELISA indices of >6.00; thus, retesting this specimen subset by BS ELISA is unnecessary.

* Corresponding author. Mailing address: 5785 Corporate Avenue, Cypress, CA 90630. Phone: (714) 503-2047. Fax: (714) 821-3364. E-mail: hprince{at}focusdx.com

{triangledown} Published ahead of print on 18 June 2008.

Clinical and Vaccine Immunology, August 2008, p. 1304-1306, Vol. 15, No. 8
1071-412X/08/$08.00+0     doi:10.1128/CVI.00157-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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