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Clinical and Vaccine Immunology, May 2008, p. 893-896, Vol. 15, No. 5
1071-412X/08/$08.00+0     doi:10.1128/CVI.00477-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Mice with Pulmonary Tuberculosis Treated with Mycobacterium vaccae Develop Strikingly Enhanced Recall Gamma Interferon Responses to M. vaccae Cell Wall Skeleton{triangledown}

Elisabeth Rodríguez-Güell,1 Gemma Agustí,1 Mercè Corominas,2 Pere-Joan Cardona,3 Marina Luquin,1 and Esther Julián1*

Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Catalonia, Spain,1 Servei d'All·èrgia, Hospital Universitari de Bellvitge, 08907, L'Hospitalet de Llobregat, Catalonia, Spain,2 Unitat de Tuberculosi Experimental, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, 08916, Badalona, Catalonia, Spain3

Received 5 December 2007/ Returned for modification 15 January 2008/ Accepted 2 March 2008

Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma interferon in splenocytes from both non-TB and TB M. vaccae-treated mice.

* Corresponding author. Mailing address: Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Catalonia, Spain. Phone: 34 93 5813096. Fax: 34 93 5812387. E-mail: esther.julian{at}uab.es

{triangledown} Published ahead of print on 12 March 2008.

Clinical and Vaccine Immunology, May 2008, p. 893-896, Vol. 15, No. 5
1071-412X/08/$08.00+0     doi:10.1128/CVI.00477-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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Copyright © 2008 by the American Society for Microbiology. All rights reserved.