This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mahdi, N.
Right arrow Articles by Almawi, W. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mahdi, N.
Right arrow Articles by Almawi, W. Y.

 Previous Article  |  Next Article 

Clinical and Vaccine Immunology, April 2008, p. 729-731, Vol. 15, No. 4
1071-412X/08/$08.00+0     doi:10.1128/CVI.00425-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

HLA Class II Haplotypes Distinctly Associated with Vaso-Occlusion in Children with Sickle Cell Disease{triangledown}

Najat Mahdi,1 Khadija Al-Ola,1 Abeer M. Al-Subaie,2 Muhallab E. Ali,2 Zaid Al-Irhayim,2 A. Qader Al-Irhayim,2 and Wassim Y. Almawi2*

Department of Pediatrics, Salmaniya Medical Complex, Manama,1 College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain2

Received 28 October 2007/ Returned for modification 14 December 2007/ Accepted 19 December 2007

We investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC). DRB1*100101 was positively associated, while DRB1*140101, DRB1*150101, and DQB1*060101 were negatively associated, with VOC. Both susceptible (DRB1*100101-DQB1*050101) and protective (DRB1*110101-DQB1*030101 and DRB1*150101-DQB1*060101) haplotypes were identified, indicating that HLA class II haplotypes influence VOC risk.

* Corresponding author. Mailing address: Department of Medical Biochemistry, College of Medicine & Medical Sciences, Arabian Gulf University, P.O. Box 22979, Manama, Bahrain. Phone: 973-39717118. Fax: 973-17271090. E-mail: wassim{at}agu.edu.bh

{triangledown} Published ahead of print on 13 February 2008.

Clinical and Vaccine Immunology, April 2008, p. 729-731, Vol. 15, No. 4
1071-412X/08/$08.00+0     doi:10.1128/CVI.00425-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»