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Clinical and Vaccine Immunology, April 2008, p. 720-725, Vol. 15, No. 4
1071-412X/08/$08.00+0     doi:10.1128/CVI.00224-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Porcine Reproductive and Respiratory Syndrome Virus Infects Mature Porcine Dendritic Cells and Up-Regulates Interleukin-10 Production

Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo, A.C., Hermosillo, Sonora 83000, Mexico,¹ Department of Veterinary and Biomedical Sciences, University of Nebraska—Lincoln, Lincoln, Nebraska 68583-0905²

Received 1 June 2007/ Returned for modification 8 September 2007/ Accepted 1 February 2008

Porcine reproductive and respiratory syndrome virus (PRRSV) infects mature dendritic cells (mDCs) derived from porcine monocytes and matured with lipopolysaccharide. The infection of mDCs induced apoptosis, reduced the expression of CD80/86 and major histocompatibility complex class II molecules, and increased the expression of interleukin-10, thus suggesting that such mDC modulation results in the impairment of T-cell activation.

Published ahead of print on 13 February 2008.